반응 #65389

반응 방정식

2-(6-amino-3,4-dihydro-2,2-dimethyl-2H-1,4-benzoxazin-4-yl)pyridine N-oxide

acetic anhydride

→

2-(6-acetamido-3,4-dihydro-2,2-dimethyl-2H-1,4-benzoxazin-4-yl)pyridine N-oxide

반응 조건

후처리

1. 1
   농축After concentration
2. 2
   workup.DISSOLUTIONthe residue was dissolved in chloroform
3. 3
   세척washed with saturated aqueous sodium hydrogen carbonate solution
4. 4
   기타dried
5. 5
   농축concentrated
6. 6
   기타The residue was recrystallized from chloroform-ether

실험 절차

To a solution of 0.474 g of 2-(6-amino-3,4-dihydro-2,2-dimethyl-2H-1,4-benzoxazin-4-yl)pyridine N-oxide in 5 ml of acetic anhydride was added 3 drops of pyridine and the mixture was stirred at room temperature for 63 hours. After concentration, the residue was dissolved in chloroform, washed with saturated aqueous sodium hydrogen carbonate solution, dried and concentrated. The residue was recrystallized from chloroform-ether to give 0.285 g of 2-(6-acetamido-3,4-dihydro-2,2-dimethyl-2H-1,4-benzoxazin-4-yl)pyridine N-oxide.

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