반응 #653779

반응 방정식

sulfuryl chloride

3-(4-chloro-2-fluoro-5-methylphenyl)-5-difluoromethoxy-1-methyl-1H-pyrazole

sodium hydrogen carbonate

→

4-Chloro-3-(4-chloro-2-fluoro-5-methylphenyl)-5-difluoromethoxy-1-methyl-1H-pyrazole

용매

tetrachloromethane

반응 조건

후처리

1. 1
   기타The organic phase was then separated off
2. 2
   세척washed
3. 3
   건조dried over magnesium sulfate
4. 4
   여과filtered
5. 5
   농축finally concentrated

실험 절차

22 g (0.16 mol) of sulfuryl chloride were added dropwise to a solution of 43 g (0.15 mol) of 3-(4-chloro-2-fluoro-5-methylphenyl)-5-difluoromethoxy-1-methyl-1H-pyrazole in 250 ml of tetrachloromethane. After the reaction solution had subsequently been stirred for 16 hours, 200 ml of saturated aqueous sodium hydrogen carbonate solution was added dropwise. The organic phase was then separated off, washed using saturated sodium chloride solution, dried over magnesium sulfate, then filtered and finally concentrated. Yield: 46 g.

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