반응 #653014

반응 방정식

aluminum chloride

7-methoxy-1-tetralone

hydrochloric acid

→

7-hydroxy-1-tetralone

수율 79.1%

용매

xylene

반응 조건

후처리

1. 1
   온도the mixture was refluxed for 4.5 hours
2. 2
   추출the mixture was extracted with ethyl acetate
3. 3
   기타The organic layer was separated
4. 4
   농축concentrated under reduced pressure
5. 5
   기타The residue was separated
6. 6
   기타purified with column chromatography (ethyl acetate)

실험 절차

In xylene (450 ml) was dissolved 7-methoxy-1-tetralone (50.0 g) under argon atmosphere. To the mixture was added aluminum chloride (75.7 g), and the mixture was refluxed for 4.5 hours. The mixture was cooled to room temperature. To the mixture was added 3N hydrochloric acid (500 ml), and the mixture was extracted with ethyl acetate. The organic layer was separated and concentrated under reduced pressure. The residue was separated and purified with column chromatography (ethyl acetate) to give 7-hydroxy-1-tetralone (36.4 g) as dark green crystals.

출처