반응 #652699

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1-chloro-4-(1H-indole-4-oxy)butane

6-chloro-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole

potassium carbonate

→

title compound

4-[4-(6-chloro-3-indolyl)-1,2,3,6-tetra-hydropyridin-1-yl]-1-(4-indolyloxy)butane

용매

dimethylformamide

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실험 절차

The title compound was prepared in a fashion similar to that described in Example 99 using 1-chloro-4-(1H-indole-4-oxy)butane (0.479 g, 2.15 mmol) and 6-chloro-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole ( 0.500 g, 2.13 mmol) in the presence of 2.5 equivalents of potassium carbonate (0.742 g, 5.38 mmol) in dimethylformamide at 90° C. Yield 0.220 g (24%) of a tan foam. FDMS m/e=420 (M+ of free base).

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