반응 #652686

반응 방정식

1-(4-indolyloxy)-3-chloropropane

3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole

sodium carbonate

→

yellow crystals

수율 52.2%

1-(4-indolyloxy)-3-[4-(1H-indol-3-yl)-1,2,3,6-tetrahydropyridin-1-yl]propane

수율 52.2%

용매

dimethylformamide

반응 조건

후처리

1. 1
   기타Evaporation of dimethylformamide, dilution
2. 2
   기타with water and crystallization of the resulting precipitate from ethanol

실험 절차

The above 1-(4-indolyloxy)-3-chloropropane (0.629g, 3 mmol), 3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole (0.595 g, 3 mmol) and sodium carbonate (0.795 g, 7.5 mmol) were mixed together in 15 mL dimethylformamide. This mixture was heated at 100° C. for 18 h. Evaporation of dimethylformamide, dilution with water and crystallization of the resulting precipitate from ethanol provided 0.582 g of yellow crystals. Mp 192-194° C. Mass spectrum, m+=371. Anal (C24H25N3O) theory C, 77.60; H, 6.78; N, 11.31; found C, 77.49; H, 6.53; N, 11.29.

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