반응 #65249

반응 방정식

2-n-butyl-1-(2-chlorophenyl)methyl-5-hydroxymethyl-1H-imidazole

→

2-n-butyl-1-(2-chlorophenyl)methyl-1H-imidazol-5-carboxaldehyde

수율 78.0%

용매

toluene

methylene chloride

반응 조건

후처리

1. 1
   여과The solids were filtered
2. 2
   농축the filtrate concentrated
3. 3
   기타flash chromatographed over silica gel with 6:4 hexane/ethyl acetate

실험 절차

A solution of 2-n-butyl-1-(2-chlorophenyl)methyl-5-hydroxymethyl-1H-imidazole (5.4 g, 0.0194 mol) in toluene (25 mL) was added to a suspension of activated manganese dioxide (27 g) in methylene chloride (325 mL). The suspension was stirred at room temperature for 17 hours. The solids were filtered and the filtrate concentrated and flash chromatographed over silica gel with 6:4 hexane/ethyl acetate to afford 4.16 g (78%) of 2-n-butyl-1-(2-chlorophenyl)methyl-1H-imidazol-5-carboxaldehyde, as an oil. NMR and IR were consistent with the structure.

출처