반응 #65206

반응 방정식

6-(2-chlorobenzoyl)-5-(2-chlorobenzoylamino)indan

ammonia

→

5-amino-6-(2-chlorobenzoyl)indan

수율 94.4%

용매

H2SO4

—

ice water

반응 조건

후처리

1. 1
   추출extracted with ethyl acetate
2. 2
   세척The extract was washed with water
3. 3
   건조dried (MgSO4)
4. 4
   workup.DISTILLATIONthe solvent was distilled off

실험 절차

A mixture of 6-(2-chlorobenzoyl)-5-(2-chlorobenzoylamino)indan (16.0 g) and 70% H2SO4 (100 ml) was heated at 120° C. for 30 minutes and, then, poured in ice-water (300 ml). The solution was alkalinized with concentrated aqueous ammonia and extracted with ethyl acetate. The extract was washed with water and dried (MgSO4) and the solvent was distilled off to give 5-amino-6-(2-chlorobenzoyl)indan as yellow oil (10.0 g, 94.3%). Recrystallization from hexane gave yellow prisms, m.p. 90°-92°.

출처