반응 #65205

반응 방정식

HCl

5-(2-chlorobenzoylamino)indan

2-chlorobenzoyl chloride

tin tetrachloride

→

6-(2-chlorobenzoyl)-5-(2-chlorobenzoylamino)indan

수율 66.2%

용매

ethyl acetate

반응 조건

후처리

1. 1
   기타The organic layer was separated
2. 2
   세척washed with water, 2N NaOH and water in the order
3. 3
   workup.DISTILLATIONthe solvent was distilled off
4. 4
   기타The residue was chromatographed on silica gel
5. 5
   세척eluted with hexane-acetone (4:1)

실험 절차

A mixture of 5-(2-chlorobenzoylamino)indan (16 g), 2-chlorobenzoyl chloride (15.5 g) and tin tetrachloride (10.2 ml) was heated at 130° C. for 30 minutes and, then, diluted with ethyl acetate (150 ml), followed by addition of 3N HCl (150 ml). The organic layer was separated and washed with water, 2N NaOH and water in the order mentioned and the solvent was distilled off. The residue was chromatographed on silica gel and eluted with hexane-acetone (4:1) to give 6-(2-chlorobenzoyl)-5-(2-chlorobenzoylamino)indan as oil (16.0 g, 66.2%).

출처