반응 #65155

반응 방정식

3-Chloropropylsulfonyl chloride

3-chloropropylsulfonyl chloride

O-benzylhydroxylamine hydrochloride

potassium carbonate

→

N-benzyloxy-3-chloropropylsulfonamide

수율 41.0%

용매

water

ether

반응 조건

후처리

1. 1
   추출the reaction mixture was extracted with ethyl acetate
2. 2
   세척From the fraction eluted with a mixture of ethyl acetate/n-hexane (1:4)

실험 절차

3-Chloropropylsulfonyl chloride 1 (30.28 g,0.17 mol), O-benzylhydroxylamine hydrochloride (27.3 g,0.17 mol), potassium carbonate (50 g,0.36 mol) and tetrabutylammonium sulfate (about 500 mg) are reacted with each other in a mixture of ether and water (1:1) (100 ml) for 24 hours at room temperature and the reaction mixture was extracted with ethyl acetate. The extract was subjected to column chromatography on silica gel. From the fraction eluted with a mixture of ethyl acetate/n-hexane (1:4),18.4 g (41%) of crude N-benzyloxy-3-chloropropylsulfonamide (intermediate 3g) was obtained as a pale yellow oil.

출처