반응 #651455

반응 방정식

[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-[2-(1H-Indol-3-yl)-ethyl]-amine

compound E2

[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-[2-(1H-Indol-3-yl)-ethyl]-amine

(E)-3-[1-(4-bromomethyl-benzenesulfonyl)-1H-pyrrol-3-yl]-acrylic acid tert-butyl ester

compound D4

(E)-3-[1-(4-bromomethyl-benzenesulfonyl)-1H-pyrrol-3-yl]-acrylic acid tert-butyl ester

→

(E)-3-{1-[4-({[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-[2-(1H-indol-3-yl)-ethyl]-amino}-methyl)-benzenesulfonyl]-1H-pyrrol-3-yl}-acrylic acid tert-butyl ester

용매

ethanol

반응 조건

후처리

1. 1
   기타evaporated
2. 2
   기타The residue is purified by a silica gel flash chromatograph

실험 절차

[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-[2-(1H-Indol-3-yl)-ethyl]-amine (compound E2) (830 mg, 2.60 mmol) is dissolved in ethanol (200 ml). (E)-3-[1-(4-bromomethyl-benzenesulfonyl)-1H-pyrrol-3-yl]-acrylic acid tert-butyl ester (compound D4) (1.01 g, 2.37 mmol) is added and the mixture is stirred for 43 hours and evaporated. The residue is purified by a silica gel flash chromatograph using petrol ether-ether eluent.

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