반응 #651450

ord-f5885b5507084db787ab8fe0bb1afce7

반응 방정식

CC(C)(C)OC(=O)/C=C/c1ccn(S(=O)(=O)c2ccc(CBr)cc2)c1
compound D2
CC(C)(C)OC(=O)/C=C/c1ccn(S(=O)(=O)c2ccc(CBr)cc2)c1
(E)-3-[1-(4-bromomethyl-benzenesulfonyl)-1H-pyrrol-3-yl]-acrylic acid tert-butyl ester
C1COCCN1
morpholine
→
CC(C)(C)OC(=O)/C=C/c1ccn(S(=O)(=O)c2ccc(CN3CCOCC3)cc2)c1
title compound
CC(C)(C)OC(=O)/C=C/c1ccn(S(=O)(=O)c2ccc(CN3CCOCC3)cc2)c1
(E)-3-{1-[4-(Morpholin-4-yl-methyl)-benzenesulfonyl]-1H-pyrrol-3yl}-acrylic acid tert-butyl ester

반응물

CC(C)(C)OC(=O)/C=C/c1ccn(S(=O)(=O)c2ccc(CBr)cc2)c1
compound D2
CC(C)(C)OC(=O)/C=C/c1ccn(S(=O)(=O)c2ccc(CBr)cc2)c1
(E)-3-[1-(4-bromomethyl-benzenesulfonyl)-1H-pyrrol-3-yl]-acrylic acid tert-butyl ester
C1COCCN1
morpholine

시약

없음

반응 조건

상세 조건
See reaction.notes.procedure_details.

실험 절차

Starting from compound D2 and morpholine the title compound can be obtained analogously as described for compound C5.

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US08067615B2uspto-grants-2011_11