반응 #651446

ord-2abdedd2c71043feb858ca83d91a8789

반응 방정식

O=S(=O)(Cl)c1ccc(-c2ccccc2)cc1
4-biphenylsulphonylchloride
[H-].[Na+]
sodium hydride
CC(C)(C)OC(=O)/C=C/c1cc[nH]c1
(E)-3-(1H-pyrrol-3-yl)-acrylic acid tert-butyl ester
CC(C)(C)OC(=O)/C=C/c1cc[nH]c1
(E)-3-(1H-pyrrol-3-yl)acrylic acid tert-butyl ester
CC(C)(C)OC(=O)/C=C/c1cc[nH]c1
compound D1
CC(C)(C)OC(=O)/C=C/c1cc[nH]c1
(E)-3-(1H-pyrrol-3-yl)acrylic acid tert-butyl ester
→
CC(C)(C)OC(=O)/C=C/c1ccn(S(=O)(=O)c2ccc(-c3ccccc3)cc2)c1
(E)-3-[1-(Biphenyl-4-sulfonyl)-1H-pyrrol-3-yl]-acrylic acid tert-butyl ester

반응물

O=S(=O)(Cl)c1ccc(-c2ccccc2)cc1
4-biphenylsulphonylchloride
[H-].[Na+]
sodium hydride
CC(C)(C)OC(=O)/C=C/c1cc[nH]c1
(E)-3-(1H-pyrrol-3-yl)-acrylic acid tert-butyl ester
CC(C)(C)OC(=O)/C=C/c1cc[nH]c1
(E)-3-(1H-pyrrol-3-yl)acrylic acid tert-butyl ester
CC(C)(C)OC(=O)/C=C/c1cc[nH]c1
compound D1
CC(C)(C)OC(=O)/C=C/c1cc[nH]c1
(E)-3-(1H-pyrrol-3-yl)acrylic acid tert-butyl ester

시약

없음

반응 조건

상세 조건
See reaction.notes.procedure_details.

후처리

  1. 1
    기타Reaction conditions
  2. 2
    기타−30° C., 10 min
  3. 3
    기타30° C., 30 min.

실험 절차

Starting materials: sodium hydride 60% (0.207 g), (E)-3-(1H-pyrrol-3-yl)-acrylic acid tert-butyl ester (compound D1) (0.531 g), 4-biphenylsulphonylchloride (0.834 g). Reaction conditions: −30° C., 10 min; 30° C., 30 min.

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US08067615B2uspto-grants-2011_11