반응 #65137
ord-45ad84a776d8497a82a3788ad950e171
반응 방정식
반응 조건
상세 조건
See reaction.notes.procedure_details.
후처리
- 1여과The mixture was filtered
- 2세척the inorganic salts washed with ethyl acetate (2×50 ml)
- 3농축concentrated in vacuo
실험 절차
A solution of (2,3-dihydrobenzofuran-5-yl)acetic acid (4.9 g - see EP-A-132130) in anhydrous tetrahydrofuran (50 ml) was added dropwise over 10 minutes to a stirred suspension of lithium aluminium hydride (1.57 g) in anhydrous tetrahydrofuran (50 ml) at 0° C. The mixture was allowed to warm to room temperature and stirred for 1 hour. Water (1.5 ml) was cautiously added dropwise followed by 10% aqueous sodium hydroxide (1.5 ml) and, finally, water (4.5 ml). The mixture was filtered and the inorganic salts washed with ethyl acetate (2×50 ml). The filtrate and washings were combined and concentrated in vacuo to give the title compound as an oil, yield 3.3 g.