반응 #65117

ord-8af7348eff6e439ca9acd651f7754427

반응 방정식

O=C(O)C[C@H](NC(=O)c1ccccc1)C(=O)O
N-benzoyl-L-aspartic acid
COC(=O)[C@@H](N)Cc1ccccc1
L-phenylalanine methyl ester
COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)c1ccccc1
N-benzoyl-L-aspartyl-L-phenylalanine methyl ester
수율 64.2%

반응 조건

상세 조건
See reaction.notes.procedure_details.

실험 절차

The procedure of Example 9 was followed excepting that: the quantity of N-benzoyl-L-aspartic acid was 2.85 g (10 mmol) and of the L-phenylalanine methyl ester was 2.69 g (15 mmol), in place of polyethylene glycol 600, polyethylene glycol 200 was used, the reaction time was 7 hours. N-benzoyl-L-aspartyl-L-phenylalanine methyl ester was obtained in the yield of 64.2%.

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US05418146uspto-grants-1995_05