반응 #64997

반응 방정식

4-chloro-4'-nitrobenzophenone

→

desired product

수율 79.2%

4-amino-4'-chloro-benzophenone

수율 79.2%

용매

ethanol

반응 조건

후처리

1. 1
   여과was filtered
2. 2
   기타evaporated
3. 3
   기타purified by flash column chromatography (2-8% EtOAc/CH2C12)

실험 절차

A suspension of 14.4g (54.8 mmol) of 4-chloro-4'-nitrobenzophenone and 66.9 mg, (0.5 mole %) of platinum oxide was stirred under hydrogen in 300 ml of ethanol for 2 hours The mixture was filtered, evaporated and purified by flash column chromatography (2-8% EtOAc/CH2C12) to obtain 10.05 g (72%) of the desired product as a yellow solid. 1H nmr (CDCl3) δ4.16 (2H, br s), 6.67 (2H, d), 7.43 (2H, d), 7.68 (2H, d), 7.69 (2H, d).

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