반응 #649861

ord-a3a26aa01d6a476d81ac55d13b998912

반응 방정식

Cc1cc(NC(=O)NS(=O)(=O)c2ccc(Cl)s2)ccc1N
N-(4-amino-3-methylphenyl){[(5-chloro(2-thienyl))sulfonyl]amino}-carboxamide
F[P-](F)(F)(F)(F)F.O=C(O)Cc1ccccc1.c1ccc2c(c1)nnn2O[P+](N1CCCC1)(N1CCCC1)N1CCCC1
PhCH2COOH PyBOP
→
Cc1cc(NC(=O)NS(=O)(=O)c2ccc(Cl)s2)ccc1NCc1ccccc1
{[(5-chloro(2-thienyl))sulfonyl]amino}-N-{3-methyl-4-[benzylamino]phenyl}carboxamide

반응물

Cc1cc(NC(=O)NS(=O)(=O)c2ccc(Cl)s2)ccc1N
N-(4-amino-3-methylphenyl){[(5-chloro(2-thienyl))sulfonyl]amino}-carboxamide
F[P-](F)(F)(F)(F)F.O=C(O)Cc1ccccc1.c1ccc2c(c1)nnn2O[P+](N1CCCC1)(N1CCCC1)N1CCCC1
PhCH2COOH PyBOP

시약

없음

반응 조건

상세 조건
See reaction.notes.procedure_details.

실험 절차

1.0 equivalent of N-(4-amino-3-methylphenyl){[(5-chloro(2-thienyl))sulfonyl]amino}-carboxamide was treated with 1.0 equivalent of PhCH2COOH/PyBOP to give X═CH2, {[(5-chloro(2-thienyl))sulfonyl]amino}-N-{3-methyl-4-[benzylamino]phenyl}carboxamide. ES-MS (M+H)+=464, 466 (Cl).

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US08067428B2uspto-grants-2011_11