반응 #64984

반응 방정식

ethyl 2-(2,3,4,5,6-pentafluorobenzoyl)-3-(2,4-difluorophenylamino)acrylate

sodium fluoride

→

title compound

수율 94.6%

Ethyl 5,6,7,8-tetrafluoro-1-(2,4-difluorophenyl)-1,4-dihydro-4-oxo-3-quinolinecarboxylate

수율 94.6%

용매

dimethylformamide

반응 조건

후처리

1. 1
   온도is heated at 140°-150° C. for 3 hours
2. 2
   여과the precipitate is filtered off with suction
3. 3
   세척washed with water
4. 4
   기타dried

실험 절차

A mixture of 135.4 g of ethyl 2-(2,3,4,5,6-pentafluorobenzoyl)-3-(2,4-difluorophenylamino)acrylate, 20.6 g of sodium fluoride and 300 ml of anhydrous dimethylformamide is heated at 140°-150° C. for 3 hours. The suspension is poured hot onto 2 kg of ice and the precipitate is filtered off with suction, washed with water and dried. 122 g of the title compound of melting point 160°-162° C. are obtained.

출처