반응 #64983

반응 방정식

2,4-difluoroaniline

ethyl 3-ethoxy-2-(2,3,4,5,6-pentafluorobenzoyl)-acrylate

water

→

title compound

수율 94.5%

Ethyl 2-(2,3,4,5,6-pentafluorobenzoyl)-3-(2,4-difluorophenylamino)-acrylate

수율 94.5%

용매

ethanol

반응 조건

후처리

1. 1
   온도while cooling with ice
2. 2
   workup.STIRRINGThe mixture is stirred at room temperature for 1 hour
3. 3
   온도while cooling with ice
4. 4
   여과the precipitate is filtered off with suction
5. 5
   세척washed with ethanol/H2O (1:1)
6. 6
   기타dried

실험 절차

44.3 g of 2,4-difluoroaniline are added dropwise to a solution of 115 g of ethyl 3-ethoxy-2-(2,3,4,5,6-pentafluorobenzoyl)-acrylate in 380 ml of ethanol, while cooling with ice and stirring. The mixture is stirred at room temperature for 1 hour, 380 ml of water are added, while cooling with ice, and the precipitate is filtered off with suction, washed with ethanol/H2O (1:1) and dried. 135.4 g of the title compound of melting point 97°-99° C. are obtained.

출처