반응 #64981

반응 방정식

water

sodium hydroxide

water

5-methyl-hexahydropyridine-2,3-dicarboxylic acid N-benzylimide

lithium aluminum hydride

→

8-Benzyl-4-methyl-2,8-diazabicyclo[4.3.0]nonane

용매

tetrahydrofuran

tetrahydrofuran

tetrahydrofuran

반응 조건

후처리

1. 1
   온도under reflux
2. 2
   여과The salts are filtered off
3. 3
   농축the filtrate is concentrated by evaporation
4. 4
   workup.DISTILLATIONthe residue is distilled

실험 절차

13.0 g of crude 5-methyl-hexahydropyridine-2,3-dicarboxylic acid N-benzylimide are added in the form of a solution in 50 ml of absolute tetrahydrofuran to 4.6 g (0.12 mol) of lithium aluminum hydride in 100 ml of absolute tetrahydrofuran, already present in the vessel. Then the mixture is boiled for 17 hours under reflux. 4.6 g of water in 14 ml of tetrahydrofuran, 4.6 g of 10% strength sodium hydroxide solution and 13.8 g of water are added dropwise one after the other. The salts are filtered off, the filtrate is concentrated by evaporation and the residue is distilled.

출처