반응 #64976

반응 방정식

ethyl 2,4-dimethyl-3-oxa-2,7-diazabicyclo[3.3.0]octane-7-carboxylate

K2CO3

→

2,4-Dimethyl-3-oxa-2,7-diazabicyclo[3.3.0]octane

용매

water

반응 조건

후처리

1. 1
   기타overnight
2. 2
   여과the BaCO3 is filtered off with suction
3. 3
   추출the filtrate is extracted several times with CHCl3
4. 4
   건조The extract is dried over K2CO3
5. 5
   농축concentrated
6. 6
   workup.DISTILLATIONthe residue is distilled

실험 절차

13.2 g (61.6 mmol) of ethyl 2,4-dimethyl-3-oxa-2,7-diazabicyclo[3.3.0]octane-7-carboxylate are heated under reflux with 39 g of Ba(OH)2.8HaO in 200 ml of water overnight. K2CO3 is added, the BaCO3 is filtered off with suction and the filtrate is extracted several times with CHCl3. The extract is dried over K2CO3 and concentrated and the residue is distilled.

출처