반응 #649744

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Imatinib

Methanesulfonic acid

→

imatinib mesylate

용매

1,3-dioxolane

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실험 절차

Imatinib base (1 g) was suspended in aqueous 1,3-dioxolane (5 ml, 10% of water, v/v) at 15° C. Methanesulfonic acid (0.125 ml) was added obtaining the solution of imatinib mesylate. The solution thus formed was cool down to about 10° C. and additional portion of 1,3-dioxolane (15 ml) was added into the mixture. The suspension was stirred at 5° C. for 10 min and the white solid was filtered, washed with 1,3-dioxolane, and the solid matter was dried at 25° C. under N2 flow for 4 h to obtain imatinib mesylate Form VI (0.6 g, yield: 50%).

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