반응 #649596

반응 방정식

Bromotrimethylsilane

4-fluorophenyl-phosphonic acid diethyl ester

→

4-fluorophenyl-phosphonic acid bis(trimethylsilyl) ester

반응 조건

후처리

1. 1
   온도to warm to ambient temperature
2. 2
   workup.STIRRINGstirred for an additional hour
3. 3
   농축The mixture was then concentrated by rotary evaporation

실험 절차

Bromotrimethylsilane (15.3 mL, 0.116 mol) was added dropwise to 4-fluorophenyl-phosphonic acid diethyl ester (8.95 g, 38.58 mmol) stirred in a reaction flask chilled to 0° C. The resulting solution was allowed to warm to ambient temperature and stirred for an additional hour. The mixture was then concentrated by rotary evaporation yielding crude 4-fluorophenyl-phosphonic acid bis(trimethylsilyl) ester which was used in the next step without further purification.

출처