반응 #64952

반응 방정식

1-methyl-pyridinium-2,3-dicarboxylic acid N-benzylimide iodide

hydrogen

→

6-Benzyl-1-methyl-5,7-dioxo-octahydropyrrolo[3,4-b]pyridine

용매

glycol monomethyl ether

반응 조건

후처리

1. 1
   기타(51 hours)
2. 2
   여과The catalyst is then filtered off
3. 3
   농축the filtrate is concentrated
4. 4
   세척the solution is washed 2× with 300 ml of 10% strength sodium carbonate solution each time
5. 5
   건조After drying over sodium sulphate, it
6. 6
   농축is concentrated

실험 절차

38 g (0.1 mol) of 1-methyl-pyridinium-2,3-dicarboxylic acid N-benzylimide iodide are hydrogenated over 1 g of platinum oxide in 450 ml of glycol monomethyl ether at 30° C. under 70 bar until the uptake of hydrogen has ended (51 hours). The catalyst is then filtered off, the filtrate is concentrated, the residue is taken up in 300 ml of chloroform and the solution is washed 2× with 300 ml of 10% strength sodium carbonate solution each time and with 300 ml of water. After drying over sodium sulphate, it is concentrated. 27 g of an oily residue remain.

출처