반응 #64946

반응 방정식

sodium hydride

1-benzyl-3-(2-chloroethylamino)-pyrrolidine-2,5-dione

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product

수율 56.0%

5-Benzyl-4,6-dioxo-octahydropyrrolo[3,4-b]pyrrole

수율 56.0%

용매

dimethylformamide

반응 조건

후처리

1. 1
   workup.WAITAfter the mixture has been left
2. 2
   기타On purification by chromatography, impurities
3. 3
   세척are first eluted with ethyl acetate
4. 4
   세척the product is then eluted with ethyl acetate:methanol (3:1) (RF value 0.55)

실험 절차

17.4 g (0.58 mmol ) of sodium hydride suspension are reacted with 119 g (0.45 mol) of 1-benzyl-3-(2-chloroethylamino)-pyrrolidine-2,5-dione in 550 ml of absolute dimethylformamide in accordance with the working instructions of Example Ib. After the mixture has been left to stand overnight, it is worked up under aqueous conditions. On purification by chromatography, impurities are first eluted with ethyl acetate and the product is then eluted with ethyl acetate:methanol (3:1) (RF value 0.55). 57.7 g of product (56% of theory) are isolated.

출처