반응 #64941

반응 방정식

ethyl chloroformate

aminoacetaldehyde dimethyl acetal

NaOH

→

Ethyl N-(2,2-dimethoxyethyl)-carbamate

용매

toluene

water

반응 조건

후처리

1. 1
   기타the aqueous phase is separated off, saturated with sodium chloride
2. 2
   추출extracted with toluene
3. 3
   건조The toluene solutions are dried over magnesium sulphate
4. 4
   농축concentrated
5. 5
   workup.DISTILLATIONthe residue is distilled

실험 절차

214 g (2 mol) of ethyl chloroformate are added dropwise to 214 g (2 mol) of aminoacetaldehyde dimethyl acetal in 1 l of toluene and 90 g of NaOH in 500 ml of water at 10° C. The mixture is stirred at room temperature for a further 2 hours and the aqueous phase is separated off, saturated with sodium chloride and extracted with toluene. The toluene solutions are dried over magnesium sulphate and concentrated and the residue is distilled.

출처