반응 #64938
ord-ae9ad9396f1647d8839a5608d03b21af
반응 방정식
3-Benzyl-6-oxa-3-azabicyclo [3.1.0]hexane
2-(benzylamino)-ethanol
→
trans-1-benzyl-3-[N-benzyl-N-(2-hydroxyethyl)-amino]-4-hydroxypyrrolidine
반응 조건
상세 조건
See reaction.notes.procedure_details.
실험 절차
3-Benzyl-6-oxa-3-azabicyclo [3.1.0]hexane is reacted with 2-(benzylamino)-ethanol, analogously to Example D a), to give trans-1-benzyl-3-[N-benzyl-N-(2-hydroxyethyl)-amino]-4-hydroxypyrrolidine which is then reacted analogously to Example F a) to give 5,8-dibenzyl-2-oxa-5,8-diazabicyclo[4.3.0]nonane which is purified by chromatography (silica gel, cyclohexane/tert.-butyl methyl ether/ethyl acetate 1:1:1).