반응 #649024

반응 방정식

3-(4-bromophenyl)propan-1-ol

imidazole

tert-butyldimethylsilyl chloride

→

title compound

[3-(4-Bromophenyl)propoxy](tert-butyl)dimethylsilane

용매

DMF

반응 조건

후처리

1. 1
   기타The reaction mixture was quenched with sat. aq. NH4Cl
2. 2
   추출extracted with hexanes
3. 3
   세척The combined organic extracts were washed further with water and brine

실험 절차

To a solution of 3-(4-bromophenyl)propan-1-ol (1 eq.) in DMF (0.25 M) was added imidazole (1.2 eq.) and tert-butyldimethylsilyl chloride (1.1 eq.). The resulting solution was stirred at RT for 13 h. The reaction mixture was quenched with sat. aq. NH4Cl and extracted with hexanes. The combined organic extracts were washed further with water and brine. Concentration of the organic extracts in vacuo afforded the title compound as a colorless oil.

출처