반응 #648803

반응 방정식

potassium cyanide

compound

3-(4-Chlorophenyl)-3-cyclopropyl-3-{7-[(methylsulfanyl)methyl]-1H-indol-3-yl}propyl methanesulfonate

water

→

4-(4-Chlorophenyl)-4-cyclopropyl-4-{7-[(methylsulfanyl)methyl]-1H-indol-3-yl}butanonitrile

용매

DMSO

반응 조건

후처리

1. 1
   기타the crude product was purified directly by preparative HPLC (mobile phase: acetonitrile/water gradient)
2. 2
   기타29 mg (60% of theory) of the target compound were obtained

실험 절차

16 mg (0.25 mmol) of potassium cyanide were added to 57 mg (0.12 mmol) of the compound from Example 116A in 1 ml of DMSO. The mixture was stirred at 80° C. for 16 h, water was added to the reaction solution, and the crude product was purified directly by preparative HPLC (mobile phase: acetonitrile/water gradient). 29 mg (60% of theory) of the target compound were obtained.

출처