반응 #648800

반응 방정식

potassium cyanide

compound

3-{7-[(Methylsulfanyl)methyl]-1H-indol-3-yl}-3-[4-(trifluoromethyl)phenyl]butyl methanesulfonate

water

dichloromethane

→

4-{7-[(Methylsulfanyl)methyl]-1H-indol-3-yl}-4-[4-(trifluoromethyl)phenyl]pentanonitrile

용매

DMSO

반응 조건

후처리

1. 1
   기타the phases were separated
2. 2
   추출The organic phase was extracted with dichloromethane
3. 3
   기타The crude product was purified by preparative HPLC (mobile phase: acetonitrile/water gradient)
4. 4
   기타62 mg (62% of theory) of the target compound were obtained

실험 절차

33 mg (0.50 mmol) of potassium cyanide were added to 118 mg (0.25 mmol) of the compound from Example 113A in 1.5 ml of DMSO. The mixture was stirred at 80° C. for 4 h, water and dichloromethane were added to the reaction solution, and the phases were separated. The organic phase was extracted with dichloromethane, and the combined organic phases were freed of solvent. The crude product was purified by preparative HPLC (mobile phase: acetonitrile/water gradient). 62 mg (62% of theory) of the target compound were obtained.

출처