반응 #648799

반응 방정식

potassium cyanide

compound

3-(2,2-Difluoro-1,3-benzodioxol-5-yl)-3-{7-[(methylsulfanyl)methyl]-1H-indol-3-yl}propyl methanesulfonate

ethyl acetate

→

4-(2,2-Difluoro-1,3-benzodioxol-5-yl)-4-{7-[(methylsulfanyl)methyl]-1H-indol-3-yl}butanonitrile

용매

DMSO

반응 조건

후처리

1. 1
   세척the mixture was washed twice with water and once with saturated aqueous sodium chloride solution
2. 2
   기타the crude product was purified by preparative HPLC (mobile phase: acetonitrile/water gradient)
3. 3
   기타0.90 g (78% of theory) of the target compound was obtained

실험 절차

0.37 g (5.76 mmol) of potassium cyanide was added to 1.35 g (2.88 mmol) of the compound from Example 112A in 26 ml of DMSO. The mixture was stirred at 80° C. for 3 h, ethyl acetate was added to the reaction solution, and the mixture was washed twice with water and once with saturated aqueous sodium chloride solution. The combined organic phases were freed of solvent, and the crude product was purified by preparative HPLC (mobile phase: acetonitrile/water gradient). 0.90 g (78% of theory) of the target compound was obtained.

출처