반응 #648787

반응 방정식

water

acetonitrile

compound

Ethyl 3-(2,2-difluoro-1,3-benzodioxol-5-yl)-3-{7-[(methylsulfanyl)methyl]-1H-indol-3-yl}propanoate

lithium aluminum hydride

→

title compound

3-(2,2-Difluoro-1,3-benzodioxol-5-yl)-3-{7-[(methylsulfanyl)methyl]-1H-indol-3-yl}propan-1-ol

용매

tetrahydrofuran

tetrahydrofuran

tetrahydrofuran

반응 조건

후처리

1. 1
   여과the suspension was filtered through kieselguhr
2. 2
   기타The solvents were removed in a rotary evaporator
3. 3
   기타the residue was purified by preparative HPLC (mobile phase: acetonitrile/water gradient)

실험 절차

A solution of 1.67 g (3.86 mmol) of the compound from Example 103A in 8 ml of tetrahydrofuran was added dropwise to 13.5 ml (13.5 mmol) of a 1N solution of lithium aluminum hydride in tetrahydrofuran in 16 ml of tetrahydrofuran at RT under argon. The mixture was stirred at 60° C. for 1 h and then water and acetonitrile were added, and the suspension was filtered through kieselguhr. The solvents were removed in a rotary evaporator, and the residue was purified by preparative HPLC (mobile phase: acetonitrile/water gradient). 1.39 g (92% of theory) of the title compound were obtained.

출처