반응 #648780

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compound

3-[(2,4-Difluorophenyl)(4-fluorophenyl)methyl]-7-[(methylsulfanyl)methyl]-1H-indole

dichloromethane

meta-chloroperbenzoic acid

→

title compound

3-[(2,4-Difluorophenyl)(4-fluorophenyl)methyl]-7-[(methylsulfinyl)methyl]-1H-indole

용매

methanol

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후처리

1. 1
   농축the solution was concentrated
2. 2
   기타The residue was purified by preparative HPLC (mobile phase: acetonitrile/water gradient)

실험 절차

75 mg (0.19 mmol) of the compound from Example 103 were introduced into 14 ml of dichloromethane at 0° C., 47 mg (0.19 mmol) of 70% pure meta-chloroperbenzoic acid were added, and the mixture was stirred at RT for 2 h. 2 ml of methanol were added, and the solution was concentrated. The residue was purified by preparative HPLC (mobile phase: acetonitrile/water gradient). 74 mg (95% of theory) of the title compound were obtained as mixture of diastereomers.

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