반응 #64877

반응 방정식

potassium hydroxide

4-hydroxy-pyrazolidine-N,N'-dicarboxylic acid di-tert-butyl ester

chlorodifluoromethane

→

desired product

수율 33.3%

4-difluoromethoxy-pyrazolidine- N,N'-dicarboxylic acid di-tert-butyl ester

수율 33.3%

용매

tetrahydrofuran

반응 조건

후처리

1. 1
   여과The reaction solution is then filtered
2. 2
   농축concentrated
3. 3
   기타purified by means of column chromatography

실험 절차

0.2 g of tetrabutylammonium fluoride and 5.6 g of potassium hydroxide powder are added to a solution of 6.9 g of 4-hydroxy-pyrazolidine-N,N'-dicarboxylic acid di-tert-butyl ester in 60 ml of tetrahydrofuran. At a maximum of 45° C., 8.0 g of chlorodifluoromethane are introduced. The reaction solution is then filtered, concentrated and purified by means of column chromatography to yield 2.7 g of the desired product, 4-difluoromethoxy-pyrazolidine-N,N'-dicarboxylic acid di-tert-butyl ester, in the form of a yellow oil.

출처