반응 #648615

반응 방정식

2,2-difluoro-1,3-benzodioxole-5-carbaldehyde

Meldrum's acid

D,L-proline

compound

7-[(Methylsulfanyl)methyl]-1H-indole

→

title compound

5-[(2,2-Difluoro-1,3-benzodioxol-5-yl){7-[(methylsulfanyl)methyl]-1H-indol-3-yl}methyl]-2,2-dimethyl-1,3-dioxane-4,6-dione

용매

acetonitrile

반응 조건

후처리

1. 1
   여과The precipitated solid was filtered off with suction
2. 2
   세척washed with acetonitrile
3. 3
   기타dried under high vacuum

실험 절차

1.57 g (8.46 mmol) of 2,2-difluoro-1,3-benzodioxole-5-carbaldehyde, 1.22 g (8.46 mmol) of Meldrum's acid and 0.05 g (0.42 mmol) of D,L-proline were added to a solution of 1.50 g (8.46 mmol) of the compound from Example 8A in 12 ml of acetonitrile. The reaction mixture was stirred at RT overnight. The precipitated solid was filtered off with suction, washed with acetonitrile and dried under high vacuum. 2.67 g (91% of theory) of the title compound were obtained.

출처