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4-acryloyl-2-chloro-2,3,4,5-tetrahydro-1,4-benzothiazepine

methanol

→

4-acryloyl-2-methoxy-2,3,4,5-tetrahydro-1,4-benzothiazepine

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실험 절차

The above-mentioned 4-acryloyl-2-chloro-2,3,4,5-tetrahydro-1,4-benzothiazepine (0.20 g), methanol (0.1 ml) and stannic chloride (0.31 g) were reacted in the same manner as in Experimental Example 13 to give 4-acryloyl-2-methoxy-2,3,4,5-tetrahydro-1,4-benzothiazepine (0.19 g). This compound (0.18 g) and 4-benzyl piperidine (0.19 g) were reacted in the same manner as in Experimental Example 5 to give 4-[3-[1-(4-benzyl)piperidinyl]propionyl]-2-methoxy-2,3,4,5-tetrahydro-1,4-benzothiazepine (0.25 g).

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