반응 #647818

반응 방정식

4-fluorobenzylamine

3,4-difluorobenzylamine

2-(3-benzyl-2-oxoimidazolidin-1-yl)-4-methylthiazole-5-carboxylic acid

→

title compound

수율 43.0%

2-(3-benzyl-2-oxoimidazolidin-1-yl)-N-(3,4-difluorobenzyl)-4-methylthiazole-5-carboxamide

수율 43.0%

반응 조건

실험 절차

Following the procedure as describe in Example 9, making variations as required to replace 4-fluorobenzylamine with 3,4-difluorobenzylamine to react with 2-(3-benzyl-2-oxoimidazolidin-1-yl)-4-methylthiazole-5-carboxylic acid, the title compound was obtained as a white powder in 43% yield: mp 152-153° C.; 1H NMR (300 MHz, DMSO-d6) δ 7.36-7.00 (m, 8H), 6.05 (s, 1H), 4.49 (d, J=5.7 Hz, 2H), 4.45 (s, 2H), 4.05 (t, J=8.4 Hz, 2H), 3.44 (t, J=8.4 Hz, 2H), 2.58 (s, 3H); 13C NMR (75 MHz, DMSO-d6) δ 162.5, 157.3, 155.3, 153.6, 152.0, 148.6, 135.2, 128.9, 128.2, 128.1, 123.6, 117.5, 116.8, 116.7, 116.6, 47.9, 42.9, 42.0, 41.6, 17.2; MS (ES+) m/z 443.0 (M+1).

출처