반응 #64717

반응 방정식

hydrogencarbonate

methanol

Compound 2

2-[Bis(4-acetoxyphenyl)methyl]-N-(2,4-dimethoxyphenyl)benzamide

→

desired product

수율 56.0%

2-[Bis(4-hydroxyphenyl)methyl]-N-(2,4-dimethoxyphenyl)benzamide

수율 56.0%

용매

sodium

반응 조건

후처리

1. 1
   온도the suspension was heated
2. 2
   온도under reflux for 30 minutes
3. 3
   농축The resulting mixture was concentrated under reduced pressure, and water
4. 4
   workup.ADDITIONwas added to the residue
5. 5
   추출The resulting mixture was extracted with ethyl acetate
6. 6
   건조the extract was dried over anhydrous magnesium sulfate
7. 7
   농축After concentration under reduced pressure
8. 8
   기타the residue was recrystallized

실험 절차

In a mixture of 50 ml of saturated aqueous sodium. hydrogencarbonate solution and 50 ml of methanol was suspended 2.6 g of Compound 2 prepared in Example 1, and the suspension was heated under reflux for 30 minutes. The resulting mixture was concentrated under reduced pressure, and water was added to the residue. The resulting mixture was extracted with ethyl acetate, and the extract was dried over anhydrous magnesium sulfate. After concentration under reduced pressure, the residue was recrystallized to afford 1.23 g of the desired product.

출처