반응 #64706

반응 방정식

Methyl isocyanide

2-methylbenzoyl chloride

hydrochloric acid

acetone

→

title compound

N-methyl-2-(2-tolyl)-2-oxoacetamide

용매

water

반응 조건

후처리

1. 1
   workup.STIRRINGthe mixture was stirred at room temperature for 1.5 hours for hydrolysis
2. 2
   추출The mixture was extracted with methylene chloride
3. 3
   세척washed with water
4. 4
   기타dried
5. 5
   기타The solvent was evaporated under reduced pressure

실험 절차

Methyl isocyanide (0.84 ml) was added to 2-methylbenzoyl chloride (1.55 g). The mixture was stirred at 60° C. for 16 hours. Then, 5N hydrochloric acid (1.5 ml) and acetone (2 ml) were added, and the mixture was stirred at room temperature for 1.5 hours for hydrolysis. Then, water was added. The mixture was extracted with methylene chloride, washed with water and dried. The solvent was evaporated under reduced pressure to obtain the title compound as an oil (1.68 g).

출처