반응 #64701

반응 방정식

Meldrum's acid

veratraldehyde

ethyl acetate

formic acid

→

3-(3,4-dimethoxyphenyl)propionic acid

용매

triethylamine

반응 조건

후처리

1. 1
   기타prepared
2. 2
   온도was heated to its boiling point during 1 hour
3. 3
   온도refluxed for 6 hours
4. 4
   workup.DISTILLATIONAfter distilling off the ethyl acetate under reduced pressure
5. 5
   workup.ADDITION100 ml of water were added

실험 절차

A reaction mixture containing 14.4 g (0.1 mol) of Meldrum's acid, 16.6 g (0.1 mol) of veratraldehyde, 100 ml of ethyl acetate and 25 ml of the mixture of formic acid and triethylamine prepared as described in Example 1 was heated to its boiling point during 1 hour and then refluxed for 6 hours. After distilling off the ethyl acetate under reduced pressure, the distillation residue was cooled to room temperature, 100 ml of water were added and the pH value of the mixture was adjusted to 1 with concentrated hydrochloric acid, then the method described in Example 1 was followed.

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