반응 #64685

반응 방정식

Meldrum's acid

formic acid

hydrochloric acid

veratraldehyde

→

3-(3,4-dimethoxyphenyl)propionic acid

용매

triethylamine

반응 조건

후처리

1. 1
   기타prepared
2. 2
   온도maintained at 90° C. for 2 hours
3. 3
   workup.ADDITIONwere added to the reaction mixture
4. 4
   기타at 5° C.
5. 5
   기타for 16 hours
6. 6
   여과After filtration the precipitate
7. 7
   세척was washed 3 times on the
8. 8
   여과filter
9. 9
   기타dried at 40° C. under reduced pressure

실험 절차

After weighing 14.4 g (0.1 mol) of Meldrum's acid and 16.6 g (0.1 mol) of veratraldehyde to 50 ml of the mixture of formic acid and triethylamine prepared according to Example 1, the reaction mixture was heated to 90° C. during 1 hour and maintained at 90° C. for 2 hours. After cooling down to room temperature 200 ml of ice-water were added to the reaction mixture, the pH value was adjusted to 1 by adding concentrated hydrochloric acid and the mixture was let stand at 5° C. for 16 hours. After filtration the precipitate was washed 3 times on the filter and dried at 40° C. under reduced pressure.

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