반응 #646715

반응 방정식

5-chloro-N-((1H-imidazol-4-yl)methyl)thiophene-2-carboxamide

1-iodo-2-fluoro-4-(2-oxopyridin-1(2H)-yl)benzene

8-hydroxyquinoline

K2CO3

→

title compound

5-Chloro-N-((1-(2-fluoro-4-(2-oxopyridin-1(2H)-yl)phenyl)-1H-imidazol-4-yl)methyl)thiophene-2-carboxamide

용매

DMSO

반응 조건

후처리

1. 1
   기타was degassed with Ar
2. 2
   기타It was then purified by HPLC

실험 절차

A mixture of 5-chloro-N-((1H-imidazol-4-yl)methyl)thiophene-2-carboxamide 3-1 prepared above (0.940 g, 2.64 mmol), 1-iodo-2-fluoro-4-(2-oxopyridin-1(2H)-yl)benzene 3-2 prepared above (0.820 g, 2.60 mmol), 8-hydroxyquinoline (0.066 g, 0.45 mmol) and K2CO3 (0.630 g, 4.56 mmol) in DMSO (8 mL) was degassed with Ar before being charged with CuI (0.090 g, 0.47 mmol). The mixture in a sealed tube was heated at 130° C. overnight. It was then purified by HPLC to give the title compound (0.480 g). MS 429.0 and 431.0 (M+H, Cl pattern).

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