반응 #64667

반응 방정식

2-ethoxyphenyl N-(2-ethoxyphenoxysulfonyl)carbamate

2-amino-4,6-dimethoxypyrimidine

→

desired product

수율 97.5%

1-(2-Ethoxyphenoxysulfonyl)-3-(4,6-dimethoxy-2-pyrimidyl)urea

수율 97.5%

용매

toluene

반응 조건

후처리

1. 1
   온도After cooling to 30° C.
2. 2
   여과the precipitate is filtered off
3. 3
   세척washed with 100 ml of toluene

실험 절차

38.1 g of 2-ethoxyphenyl N-(2-ethoxyphenoxysulfonyl)carbamate are dissolved in 500 ml of toluene, 15.5 g of 2-amino-4,6-dimethoxypyrimidine are added at room temperature, and the mixture is heated for 2 hours at 100° C. After cooling to 30° C., the precipitate is filtered off and washed with 100 ml of toluene. 38.8 g of the desired product are obtained with a purity of 98.8%, corresponding to a yield of 96.4% of theory. The melting point for the product is 147°-149° C. 6.5 g of 2-ethoxyphenol are recovered from the mother liquor by distillation.

출처