반응 #6459

반응 방정식

2-(2-Phenoxyphenyl)-2-methoxyiminoacetamide

Trifluoroacetic anhydride

→

2-(2-phenoxyphenyl)-2-methoxyiminoacetonitrile

수율 96.9%

용매

hydrochloric acid

pyridine

반응 조건

후처리

1. 1
   추출extracted with ethyl acetate
2. 2
   기타The extract was dried
3. 3
   농축concentrated
4. 4
   기타to leave a residue, which
5. 5
   기타was purified by column chromatography on silica gel

실험 절차

2-(2-Phenoxyphenyl)-2-methoxyiminoacetamide (3.77 g) was dissolved in pyridine (5.53 g). The solution was cooled to 0° C. Trifluoroacetic anhydride (4.40 g) was added dropwise. The mixture was stirred for 2 hours at 0° C., and then diluted with dil. hydrochloric acid and extracted with ethyl acetate. The extract was dried and concentrated to leave a residue, which was purified by column chromatography on silica gel to obtain 2-(2-phenoxyphenyl)-2-methoxyiminoacetonitrile (3.41 g).

출처