반응 #64585

반응 방정식

2-amino-5-chlorothiophenol

methyl (-)-(2R,3S)-2,3-epoxy-3-(4-methoxyphenyl)propionate

→

(+)-(2S,3S)-8-chloro-3-hydroxy-2-(4-methoxyphenyl)-2,3-dihydro-5H-1,5-benzothiazepine-4-one

반응 조건

실험 절차

In the same way as in Example 1, the reaction between 2-amino-5-chlorothiophenol and methyl (-)-(2R,3S)-2,3-epoxy-3-(4-methoxyphenyl)propionate affords (+)-(2S,3S)-8-chloro-3-hydroxy-2-(4-methoxyphenyl)-2,3-dihydro-5H-1,5-benzothiazepine-4-one. Melting point: 237°-241° C. [α]D20 =+91.9° (c=0.1; DMF).

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