반응 #64546

반응 방정식

5-n-butyl-2,4-dihydro-2-[2-(trifluoromethyl)phenyl]-4-[(2'-sulfamoyl-5'-propylbiphenyl-4-yl)methyl]-3H-1,2,4-triazol-3-one

2-chlorobenzoic acid

CDI

DBU

→

title compound

5-n-Butyl-4-[[2'-[N-(2-chlorobenzoyl)sulfamoyl]-5'-n-propylbiphenyl-4-yl]methyl]-2,4-dihydro-2-[2-(trifluoromethyl)phenyl]-3H-1,2,4-triazol-3-one

반응 조건

실험 절차

The title compound was prepared from 5-n-butyl-2,4-dihydro-2-[2-(trifluoromethyl)phenyl]-4-[(2'-sulfamoyl-5'-propylbiphenyl-4-yl)methyl]-3H-1,2,4-triazol-3-one (from Step E) and 2-chlorobenzoic acid (2.0 equivalents), CDI (2.0 equiv), and DBU (2.0 equiv) according to the procedure of Example 51 to give an 86% yield of the desired material as a cream-colored solid after flash chromatography, mp 67°-69° C.; homogeneous by TLC in 9:1 CH2Cl2 --MeOH; mass spectrum (FAB) m/e 711 (M+1)+.

출처