반응 #645249
ord-f392fc23c3624e0bbbb713a5ea5747e4
반응 방정식
반응 조건
온도
50°CELSIUS
상세 조건
See reaction.notes.procedure_details.
후처리
- 1온도The mixture is cooled
- 2추출The mixture is extracted 3 times with in each case 150 ml of ethyl acetate
- 3건조the extracts are dried with sodium sulphate
- 4농축concentrated
- 5기타a rotary evaporator
실험 절차
9 g (40.9 mmol) of methyl 3,5-dichloro-2-aminobenzoate and 6.3 g (81.8 mmol) of 2-(aminooxy)ethanol are initially charged in 90 ml of methanol, and 22.1 g (122.7 mmol) of sodium methoxide as a 30% strength solution in methanol are added dropwise at 20° C. The mixture is stirred at 50° C. overnight. The mixture is cooled and poured onto 400 ml of water, and the pH is adjusted to 3 using 1 N hydrochloric acid. The mixture is extracted 3 times with in each case 150 ml of ethyl acetate and the extracts are dried with sodium sulphate and concentrated using a rotary evaporator.