반응 #6451

반응 방정식

p-cyanoaniline

4-chloro-3-nitropyridine

ethanol

→

N-(4-cyanophenyl)-4-amino-3-nitropyridine

반응 조건

후처리

1. 1
   여과filtered
2. 2
   workup.ADDITIONThe solid was treated with 150 ml of boiling ethanol
3. 3
   온도cooled in ice
4. 4
   여과filtered

실험 절차

According to the method of J. C. S. Perkin Trans. I, 1979, 135, p-cyanoaniline (6.894 g, 58.4 mmol) was added to a solution of 4-chloro-3-nitropyridine (9.26 g, 58.4 mmol) in ethanol (200 ml) and the mixture was stirred at room temperature for 18 hours. The resulting yellow suspension was poured into 500 ml of ice-cold dilute ammonia and filtered. The solid was treated with 150 ml of boiling ethanol, cooled in ice, and filtered to give N-(4-cyanophenyl)-4-amino-3-nitropyridine, 12.15 g, as a bright yellow powder, m.p. 210°-211° C.

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