반응 #644698

반응 방정식

ammonium chloride

aminonitrile

Dimethylamino-(1,4-dioxa-spiro[4.5]dec-8-yl)-acetonitrile

4-chlorophenylmagnesium bromide

→

[(4-Chlorophenyl)-(1,4-dioxa-spiro[4.5]dec-8-yl)-methyl]-dimethyl-amine

용매

water

ether

ether

diethyl ether

반응 조건

후처리

1. 1
   workup.ADDITIONwere added
2. 2
   세척The organic phase was washed with water and saturated sodium chloride solution
3. 3
   기타dried
4. 4
   농축concentrated

실험 절차

A solution of the aminonitrile 3 (22.43 g, 100 mmol) in abs. ether (100 ml) was added dropwise, under argon and while cooling with ice, to a 1M solution of 4-chlorophenylmagnesium bromide in ether (200 ml, 200 mmol), and stirring was carried out for 20 h at RT. For working up the reaction mixture, saturated ammonium chloride solution (100 ml) and water (100 ml) were added, while cooling with ice, and extraction with diethyl ether (3×100 ml) was carried out. The organic phase was washed with water and saturated sodium chloride solution, dried and concentrated.

출처