반응 #644451

반응 방정식

water

sodium 3-(4-(pyridin-2-yloxymethyl)-phenyl)-oxiran-2-carboxylate

acetic acid

toluene

→

title compound

(4-(Pyridin-2-yloxymethyl)-phenyl)-acetaldehyde

용매

ethyl acetate

반응 조건

후처리

1. 1
   기타was allowed to room temperature, to the reaction mixture
2. 2
   추출extracted
3. 3
   기타the organic layer was separated
4. 4
   세척washed with saturated sodium chloride water
5. 5
   건조dried over anhydrous magnesium sulfate
6. 6
   기타The solvent thereof was evaporated under a reduced pressure

실험 절차

A mixture of sodium 3-(4-(pyridin-2-yloxymethyl)-phenyl)-oxiran-2-carboxylate described in Preparation Example 2-1-2 (9.95 g), toluene (200 mL), water (120 mL) and acetic acid (16 mL) was stirred at 73° C for 90 minutes. The reaction mixture was allowed to room temperature, to the reaction mixture was added ethyl acetate, and extracted, and then the organic layer was separated, washed with saturated sodium chloride water, and dried over anhydrous magnesium sulfate. The solvent thereof was evaporated under a reduced pressure to obtain the title compound (6.82 g).

출처