반응 #644450

반응 방정식

methyl 3-(4-(pyridin-2-yloxymethyl)-phenyl)-oxiran-2-carboxylate

water

ethanol

sodium methoxide

→

title compound

Sodium 3-(4-(pyridin-2-yloxymethyl)-phenyl)-oxiran-2-carboxylate

용매

diethyl ether

tetrahydrofuran

반응 조건

후처리

1. 1
   기타at 0° C
2. 2
   여과the precipitated solids were filtered

실험 절차

To a mixture of methyl 3-(4-(pyridin-2-yloxymethyl)-phenyl)-oxiran-2-carboxylate described in Preparation Example 2-1-1 (19.9 g) and ethanol (300 mL) were sequentially added sodium methoxide (14.2 mL, 28% methanol solution), water (1.3 mL), tetrahydrofuran (100 mL) at 0° C, which was stirred at room temperature for one hour. To the reaction mixture was added diethyl ether (200 mL), and the precipitated solids were filtered to obtain the title compound (14.3 g).

출처